Thursday, October 21, 2021

Roche’s Tecentriq/Avastin combo improves survival in liver cancer




Roche is planning to present updated data confirming that its immunotherapy combination, consisting of Tecentriq (atezolizumab) and Avastin (bevacizumab), improves overall survival (OS) in patients with a type of liver cancer.

The OS data is from the Phase III IMbrave150 study, evaluating Tecentriq plus Avastin compared to sorafenib, in people with unresectable hepatocellular carcinoma (HCC) who have not received prior systemic therapy.

An updated analysis – conducted after a median follow-up of 15.6 months – found that Tecentriq plus Avastin reduced the risk of death by 34%, with a median OS of 19.2 months, compared with 13.4 months for sorafenib.

The primary analysis from the Imbrave150 study showed that after 8.6 months follow-up, Tecentriq plus Avastin reduced the risk of death (OS) by 42%.

“These results show that Tecentriq in combination with Avastin provides the longest survival that we’ve ever seen in a front-line Phase III study in unresectable HCC,” said Levi Garraway, chief medical officer and head of Global Product Development, Roche.

“The combination, which has now been approved in more than 60 countries around the world, represents a significant treatment advancement for patients with this challenging malignancy,” he added.

The Tecentriq/Avastin combination is already approved in a number of jurisdictions, including in the US, China, Japan and EU for people with unresectable HCC.

HCC is an aggressive form of cancer that currently has limited treatment options, with over 815,000 people worldwide diagnosed with this cancer type each year.

It develops predominantly in people with cirrhosis due to chronic hepatitis (B or C) or alcohol consumption and often presents at an advanced stage.



Source link

Latest Articles

Widely used chemical linked to 1,00,000 US deaths per year: Study

NEW YORK: Daily exposure to phthalates, a group of chemicals used in everything from plastic containers to makeup, may lead to approximately 100,000 deaths...

Foods to Reduce Inflammation and Strengthen the Immune System

Did you know that you can greatly reduce inflammation and boost your immune system by simply incorporating more anti-inflammatory foods and beverages into your...

Personal Selling

INTRODUCTION Early sellers and traders were not held in high esteem. The Roman word for salesman meant ‘Cheater’ and...

Building Muscle on a Vegan Diet

There are a lot of  misconceptions surrounding veganism. The notion that those who practice it are lacking in protein and therefore muscles is the...

Electrodes in brain new hope for severe cases of epilepsy

Neurosurgeons at All India Institute of Medical Sciences have devised a new technique for operating on children suffering from a severe form of epilepsy...