Tuesday, March 29, 2022

Researchers identify molecular ‘cookie cutter’ technique for COVID-19 drug discovery




Researchers from the University of Birmingham are aiming to isolate and extract the COVID-19 encounter complex for the identification of drug target sites for the disease.

The encounter complex is formed when the COVID-19 spike attaches onto a binding site on an ACE-2 receptor.

This is a complex protein embedded in cell membranes in the lungs and cells that line the nose and airways.

The encounter complex was first isolated last year, but these methods involved full extraction of ACE-2 receptors from cell membranes.

By removing the membrane’s supportive structure, the stability of the receptor is in turn affected. This makes it difficult to study its structure and function, said the University of Birmingham researchers.

The researchers are aiming to use polymer-based molecular ‘cookie cutters’ to isolate the encounter complex and ensure it remains embedded in the cell membrane.

The aim is to preserve the full structure of the molecule in its original form and keep it stable.

The researchers will use polymers known as Styrene Maleic Anhydrides, or SMAs, with the resulting structure known as an SMA lipid particle (SMALP).

The technique was invented by Professor Tim Dafforn from the University of Birmingham’s School of Biosciences.

The SMAs used in the study were provided by Orbiscope, a large-scale producer of SMAs for high-end applications.



Source link

Latest Articles

Widely used chemical linked to 1,00,000 US deaths per year: Study

NEW YORK: Daily exposure to phthalates, a group of chemicals used in everything from plastic containers to makeup, may lead to approximately 100,000 deaths...

Foods to Reduce Inflammation and Strengthen the Immune System

Did you know that you can greatly reduce inflammation and boost your immune system by simply incorporating more anti-inflammatory foods and beverages into your...

Personal Selling

INTRODUCTION Early sellers and traders were not held in high esteem. The Roman word for salesman meant ‘Cheater’ and...

Building Muscle on a Vegan Diet

There are a lot of  misconceptions surrounding veganism. The notion that those who practice it are lacking in protein and therefore muscles is the...

Electrodes in brain new hope for severe cases of epilepsy

Neurosurgeons at All India Institute of Medical Sciences have devised a new technique for operating on children suffering from a severe form of epilepsy...