Tuesday, November 2, 2021

Novartis secures rights to Mesoblast’s remestemcel-L for ARDS




Swiss pharma Novartis has inked an exclusive licence and collaboration agreement with Mesoblast to develop remestemcel-L for acute respiratory distress syndrome (ARDS), including COVID-19-associated ARDS.

Currently, remestemcel-L is being studied in COVID-19-related ARDS in an ongoing 300-patient phase III study.

ARDS carries an approximate 40% mortality rate with the current standard of care, which includes prolonged ICU treatment and mechanical ventilation.

Under the licence agreement, Novartis will acquire the worldwide rights to develop, commercialise and manufacture remestemcel-L for ARDS and will also gain access to Mesoblast’s cell-therapy platform.

Novartis will pay $25m upfront and also invest $25m in Mesoblast equity, with additional payments and royalties dependent on the achievement of agreed development, regulatory and commercial milestones.

In addition, Novartis has the option to distribute remestemcel-L for graft versus host disease (GVHD), while both parties have rights to co-fund development and commercialisation of the drug for other non-respiratory indications.

“We believe that Novartis is uniquely placed to advance this important potential new therapy. Novartis is committed to, and has demonstrated success with, cell-based therapies and transforming care for a spectrum of respiratory diseases,” said John Tsai, head of global drug development and chief medical officer for Novartis.

“This makes remestemcel-L an important addition to our pipeline. It has the potential to be the first treatment for the most critically ill ARDS patients, and it provides us with an opportunity to apply years of specialised experience directly to the work of saving lives,” he added.

In March, a compassionate use programme, including 12 patients with COVID-19-related ARDS, demonstrated that remestemcel-L treatment was associated with an 83% survival rate.

Novartis also intends to launch a phase III study of the treatment in non-COVID-19-related ARDS after the licence agreement closes and the current COVID-19-related ARDS study completes.



Source link

Latest Articles

Widely used chemical linked to 1,00,000 US deaths per year: Study

NEW YORK: Daily exposure to phthalates, a group of chemicals used in everything from plastic containers to makeup, may lead to approximately 100,000 deaths...

Foods to Reduce Inflammation and Strengthen the Immune System

Did you know that you can greatly reduce inflammation and boost your immune system by simply incorporating more anti-inflammatory foods and beverages into your...

Personal Selling

INTRODUCTION Early sellers and traders were not held in high esteem. The Roman word for salesman meant ‘Cheater’ and...

Building Muscle on a Vegan Diet

There are a lot of  misconceptions surrounding veganism. The notion that those who practice it are lacking in protein and therefore muscles is the...

Electrodes in brain new hope for severe cases of epilepsy

Neurosurgeons at All India Institute of Medical Sciences have devised a new technique for operating on children suffering from a severe form of epilepsy...