Tuesday, October 19, 2021

N440K, a virulent mutant, is fuelling surge in some states – ET HealthWorld

The expert also raised doubts over the methods of sample collection being adopted by authorities in Maharashtra.

Hyderabad: Even as scientists are busy trying to decode the potential lethality of the double mutant Covid strain B.1.617, a team of researchers from Hyderabad and Ghaziabad has found that the mutant ‘N440K’ of the novel coronavirus is 10 to 1,000 times more infectious than certain strains now in circulation. This mutant appears to be fuelling the second wave of Covid-19 in certain pockets.

The Covid-mutant N440K, first found in Andhra Pradesh’s Kurnool city, is spreading fast in some parts of the country. Already, one-third of infections in Andhra Pradesh and Telangana have been found to be caused by this variant and in the second wave, its presence is rapidly increasing. In the past two months, Karnataka, Maharashtra, Telangana and Chhattisgarh together contributed about 50% of samples with the mutant strain, indicating its geographically-localised spread.

The research study involving scientists from Hyderabad-based Centre for Cellular and Molecular Biology and the Academy for Scientific and Innovative Research (AcSIR), Ghaziabad, reveals that the N440K variant produced 10 times higher infectious viral titres (viral load) than a prevalent A2a strain and over 1,000-fold higher titres than a much less prevalent A3i strain prototype in Caco2 (epithelial) cells.

As many as 1,555 entries with N440K substitution could be identified from across the world. Interestingly, India contributed the largest proportion of N440K variants at 33%, followed by the US and Germany, the researchers said. The proportion of the N440K variant in India has increased from 4.9% sequence earlier to 8.8% between January and April 24, they explained.

Source link

Latest Articles

Widely used chemical linked to 1,00,000 US deaths per year: Study

NEW YORK: Daily exposure to phthalates, a group of chemicals used in everything from plastic containers to makeup, may lead to approximately 100,000 deaths...

Foods to Reduce Inflammation and Strengthen the Immune System

Did you know that you can greatly reduce inflammation and boost your immune system by simply incorporating more anti-inflammatory foods and beverages into your...

Personal Selling

INTRODUCTION Early sellers and traders were not held in high esteem. The Roman word for salesman meant ‘Cheater’ and...

Building Muscle on a Vegan Diet

There are a lot of  misconceptions surrounding veganism. The notion that those who practice it are lacking in protein and therefore muscles is the...

Electrodes in brain new hope for severe cases of epilepsy

Neurosurgeons at All India Institute of Medical Sciences have devised a new technique for operating on children suffering from a severe form of epilepsy...