Wednesday, July 28, 2021

Ionis taps Progenity to create oral antisense therapies


Ionis Pharmaceuticals has teamed up with Progenity to evaluate the oral systemic delivery of antisense oligonucleotides. The collaboration combines Progenity’s ingestible capsules with Ionis’ antisense molecules.

Progenity, a provider of molecular tests for fertility and cancer risk, has stepped up its interest in the oral delivery of large molecules in recent years, leading to the initiation of a phase 1 trial of its capsules in healthy volunteers. The study is an early step in an effort that could lead to oral formulations of drugs including AbbVie’s Humira. 

The work has caught the attention of Ionis. Progenity will work with the antisense specialist to assess if technology designed to enable delivery of a drug formulated in a solution directly into the tissues of the small intestine is suitable for use with antisense oligonucleotides. The delivery technology has mainly been used with monoclonals, proteins and peptides so far.

In the first phase of the collaboration, the partners will evaluate the in vitro compatibility and performance of formulations of Progenity’s delivery technology and Ionis’ oligonucleotides. Progenity and Ionis will also assess the in vivo safety, tolerability and performance of the oral formulations in a preclinical canine model.

Ionis has a long-standing interest in the oral delivery of antisense molecules, teaming up with Johnson & Johnson in 2015 to work on locally administered gastrointestinal treatments. The work led to the delivery of candidates to J&J in 2016 and 2017. One of the candidates, ION253, moved into phase 1 last year.

Other groups are also pursuing oral delivery of antisense molecules. In 2018, Roche agreed to pay up to $36 million in near-term fees, plus potentially more than $1 billion in milestones, for access to PureTech Health’s milk-derived exosome technology. The exosomes encase drugs to protect them from the environment they will encounter in the gastrointestinal tract.



Source link

Stay Connected

1,605FansLike
11,000FollowersFollow
342FollowersFollow
775FollowersFollow

Latest Articles

Covid’s second wave proves lethal for pregnant women

At SVP Hospital in Ahmedabad – one of the major Covid-19 hospitals of the city – 148 pregnant women with Covid-19 infection were admitted...

7 Tips to Keep Your Gut Healthy

This is common to say health (and illness) starts in your gut. If you have poor gut health, you’ll experience anything from wrinkled skin, to...

SII making first batch of Covovax: Poonawalla

The first batch of Covovax, a Covid-19 vaccine developed by Novavax Inc, is being manufactured at the Serum Institute of India's Pune facility, SII...

Sputnik V is safest among all Covid-19 vaccines, no deaths recorded: Buenos Aires study

A study by the Buenos Aires Ministry of Health to monitor the safety of the Sputnik V vaccine against Covid-19 confirmed on Thursday that...

Telangana caps Covid treatment charges in private hospitals

Hyderabad: The government of Telangana on Wednesday issued orders fixing treatment and investigation charges for Covid-19 in private hospitals.The state government, which had capped...