Sunday, October 31, 2021

Eli Lilly announces mid-stage trial success for donanemab in Alzheimer’s

Donanemab, an investigational antibody developed by Eli Lilly, has demonstrated positive results in a phase IIa trial in patients with early-stage Alzheimer’s disease (AD).

The phase IIa TRAILBLAZER-ALZ study is evaluating donanemab in patients with early symptomatic AD.

In the mid-stage trial, Lilly’s anti-amyloid antibody showed a significant slowing of decline in cognition and daily function in this patient population.

Donanemab also demonstrated ‘consistent improvements’ in all secondary endpoints measuring cognition and function compared to placebo, although it did not reach statistical significance on every secondary endpoint.

“We are extremely pleased about these positive findings for donanemab as a potential therapy for people living with Alzheimer’s disease, the only leading cause of death without a treatment that slows disease progression,” said Mark Mintun, vice president of pain and neurodegeneration, Eli Lilly.

“We look forward to discussing the TRAILBLAZER-ALZ study data and next steps with global regulators. In addition, we are committed to reproducing and extending these important findings in our second ongoing pivotal donanemab trial, TRAILBLAZER-ALZ 2,” he added.

Donanemab targets a modified form of beta amyloid called N3pG. By targeting N3pG, donanemab has been shown to result in high levels of amyloid clearance, according to Lilly.

In the TRAILBLAZER-ALZ trial, patients treated with donanemab showed an 84 centiloid reduction of amyloid plaque, on average, at 76 weeks, compared to a baseline of 108 centiloids.

Patients stopped receiving donanemab and switched to placebo after their plaque level was below 25 centiloids for two consecutive measures, or below 11 centiloids at any one measure – less than 25 centiloids is ‘typical’ of a negative amyloid scan, added Lilly.

Source link

Latest Articles

Widely used chemical linked to 1,00,000 US deaths per year: Study

NEW YORK: Daily exposure to phthalates, a group of chemicals used in everything from plastic containers to makeup, may lead to approximately 100,000 deaths...

Foods to Reduce Inflammation and Strengthen the Immune System

Did you know that you can greatly reduce inflammation and boost your immune system by simply incorporating more anti-inflammatory foods and beverages into your...

Personal Selling

INTRODUCTION Early sellers and traders were not held in high esteem. The Roman word for salesman meant ‘Cheater’ and...

Building Muscle on a Vegan Diet

There are a lot of  misconceptions surrounding veganism. The notion that those who practice it are lacking in protein and therefore muscles is the...

Electrodes in brain new hope for severe cases of epilepsy

Neurosurgeons at All India Institute of Medical Sciences have devised a new technique for operating on children suffering from a severe form of epilepsy...