Sunday, October 17, 2021

BMS to pay up to $1.56bn for Agenus’ bispecific antibody programme




Bristol Myers Squibb (BMS) has agreed an exclusive license deal for Agenus’ bispecific antibody programme, gaining access to the company’s preclinical anti-TIGIT asset.

Agenus’ AGEN1777 is a preclinical antibody candidate designed to target major inhibitory receptors expressed on T and NK cells to bolster anti-tumour activity by blocking TIGIT and a second undisclosed target.

In preclinical studies, using this approach has demonstrated potential in tumour models where anti-PD-1 or anti-TIGIT monospecific antibodies alone are not effective.

BMS will pay Agenus $200m upfront and up to $1.36bn in development, regulatory and commercial milestones as well as tiered double-digit royalties on net product sales as part of the agreement.

In return, BMS will become solely responsible for the development and subsequent commercialisation of AGEN1777 and any related products globally.

Under the terms of the agreement, Agenus will retain options to conduct clinical studies under the development plan and undertake combination studies with some of its other pipeline assets.

Agenus can also choose to co-promote AGEN1777 in the US, depending upon commercialisation of the asset.

“AGEN1777’s differentiated mechanism of action provides the potential for potent anti-tumour activity; catalysing our clinical TIGIT strategy aimed at serving more patients with unmet needs in cancer,” said Debbie Law, senior vice president, head of tumour microenvironment thematic research centre, BMS.

“We look forward to working with Agenus to develop this important therapy as we continue to combat I-O resistance,” she added.

Agenus is planning to file an investigational new drug application (IND) for AGEN1777 with the US Food and Drug Administration (FDA) in the second quarter of the year.

Meanwhile, BMS will advance the research and development of the bispecific antibody in immuno-oncology for ‘high priority’ tumour indications such as non-small cell lung cancer (NSCLC).



Source link

Latest Articles

Widely used chemical linked to 1,00,000 US deaths per year: Study

NEW YORK: Daily exposure to phthalates, a group of chemicals used in everything from plastic containers to makeup, may lead to approximately 100,000 deaths...

Foods to Reduce Inflammation and Strengthen the Immune System

Did you know that you can greatly reduce inflammation and boost your immune system by simply incorporating more anti-inflammatory foods and beverages into your...

Personal Selling

INTRODUCTION Early sellers and traders were not held in high esteem. The Roman word for salesman meant ‘Cheater’ and...

Building Muscle on a Vegan Diet

There are a lot of  misconceptions surrounding veganism. The notion that those who practice it are lacking in protein and therefore muscles is the...

Electrodes in brain new hope for severe cases of epilepsy

Neurosurgeons at All India Institute of Medical Sciences have devised a new technique for operating on children suffering from a severe form of epilepsy...