Friday, October 15, 2021

AZ’s COVID-19 vaccine produces ‘encouraging’ immune response in older adults




AstraZeneca and Oxford University’s COVID-19 vaccine candidate was found to be safe and well tolerated in older adults, findings published in The Lancet confirm.

The results, from the phase II study of the vaccine candidate, show that the shot produces a similar immune response in both old and young adults. The study enrolled 560 participants – 160 aged 18-55 years and 240 aged 70 years and older.

Researchers found that the vaccine candidate, ChAdOx1 nCoV-19, appears to be better tolerated in older adults than in younger adults, a result they dubbed ‘encouraging’ as ‘older individuals are at disproportionate risk of severe COVID-19’.

Earlier this month, The UK’s Medicines and Healthcare products Regulatory Agency (MHRA) started a rolling review of AZ’s shot.

Regulators will be able to review data in real time under a rolling review process, which is designed to help speed up the approval timeline of potential vaccines for the novel coronavirus, which causes COVID-19.

AZ is currently studying the vaccine in a large-scale phase III clinical trial programme in the UK, Brazil and the US.

The candidate uses a replication-deficient chimpanzee viral vector based on a weakened version of an adenovirus (the common cold virus) that contains the genetic material of SARS-CoV-2 virus spike protein, which causes COVID-19.

AZ said in a statement earlier this month that results from the phase III trials are expected later this year, depending on the COVID-19 infection rate in the communities where the studies are being conducted.



Source link

Latest Articles

Widely used chemical linked to 1,00,000 US deaths per year: Study

NEW YORK: Daily exposure to phthalates, a group of chemicals used in everything from plastic containers to makeup, may lead to approximately 100,000 deaths...

Foods to Reduce Inflammation and Strengthen the Immune System

Did you know that you can greatly reduce inflammation and boost your immune system by simply incorporating more anti-inflammatory foods and beverages into your...

Personal Selling

INTRODUCTION Early sellers and traders were not held in high esteem. The Roman word for salesman meant ‘Cheater’ and...

Building Muscle on a Vegan Diet

There are a lot of  misconceptions surrounding veganism. The notion that those who practice it are lacking in protein and therefore muscles is the...

Electrodes in brain new hope for severe cases of epilepsy

Neurosurgeons at All India Institute of Medical Sciences have devised a new technique for operating on children suffering from a severe form of epilepsy...